Clinical Efficacy of 755 nm Laser Treatment of Lip Mucosal Pigmentation in Children with Peutz–Jeghers Syndrome

Peutz–Jeghers syndrome (PJS) is a rare genetic disorder characterized by multiple gastrointestinal polyps and mucocutaneous pigmentation. Abnormal pigmentation typically develops in infancy or childhood. As PJS-related facial can lead to psychological burden due its effects on esthetics, treatment required. Herein, we report the efficacy safety of lip mucosal using Q-switched 755 nm Alexandrite Laser children with PJS, aged 2–12 years age. A topical anesthetic was used prior application laser therapy. 100% achieved one three treatments, an excellent outcome five cases (62.5%) good (37.5%). Recurrent observed case over 6-month follow-up period. There were no adverse effects, such as scarring hyperpigmentation hypopigmentation. The did cause pain, apprehension, crying some children, requiring special attention. Although our sample size small, findings do provide support high for PJS. Further studies are required confirm these findings.